Antibody against envelope protein from human endogenous retrovirus activates neutrophils in systemic lupus erythematosus
M. Tokuyama, B. M. Gunn, A. Venkataraman, Y. M. Kong, I. Kang, M. Townsend, K. Costenbader, G. Alter, A. Iwasaki
The paper identifies an endogenous retrovirus envelope protein, ERV-K102, elevated in SLE patients, which is activated by SLE IgG to promote neutrophil activation and NET formation.
bioRxiv · Sep 20, 2019Immunology