M. Tokuyama

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

This study investigates whether COVID-19 mRNA vaccination affects pregnancy outcomes or induces anti-syncytin-1 antibodies, finding no evidence of fetal defects or increased antibody levels.

Evolution of Antibody Immunity to SARS-CoV-2

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

Detection of SARS-CoV-2 RNA by multiplex RT-qPCR

This paper develops a multiplex RT-qPCR assay for SARS-CoV-2 detection that uses existing primer/probe sets and reduces reagents, costs, time, and labor compared to singleplex assays.

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

Antibody against envelope protein from human endogenous retrovirus activates neutrophils in systemic lupus erythematosus

The paper identifies an endogenous retrovirus envelope protein, ERV-K102, elevated in SLE patients, which is activated by SLE IgG to promote neutrophil activation and NET formation.

The lupus susceptibility locus Sgp3 encodes the suppressor of endogenous retrovirus expression SNERV

This study identifies SNERV, a suppressor of endogenous retrovirus expression, as a lupus susceptibility gene, showing its role in preventing ERV overexpression and associated nephritis.

Human APOBEC3G prevents emergence of infectious endogenous retrovirus in mice

This study shows that human APOBEC3G prevents the emergence of infectious endogenous retroviruses in mice, demonstrating its in vivo antiviral activity against ERVs.

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.