Author

Y. Mechulam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

E. Schmitt· 4 shared G. Nigro· 2 shared T. Simonson· 2 shared V. Opuu· 2 shared A. des Georges· 1 shared C. Lazennec· 1 shared C. Lazennec-Schurdevin· 1 shared E. Larquet· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

E. Schmitt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Visualization of translation reorganization upon persistent collision stress in mammalian cells

J. Fedry, J. Silva, M. Vanevic, S. Fronik, Y. Mechulam, E. Schmitt, A. des Georges, W. Faller, F. Förster

The paper visualizes how translation reorganizes in mammalian cells under persistent collision stress, revealing changes in ribosome complexes and quality control mechanisms.

bioRxiv · Mar 23, 2023 · PreprintCell Biology

Redesigning methionyl-tRNA synthetase for β-methionine activity with adaptive landscape flattening and experiments

V. Opuu, G. Nigro, C. Lazennec, Y. Mechulam, E. Schmitt, T. Simonson

The paper redesigns methionyl-tRNA synthetase to increase activity towards β-methionine using computational protein design and experimental validation.

bioRxiv · Dec 28, 2022Biochemistry

Role of aIF5B in archaeal translation initiation

R. Kazan, G. Bourgeois, C. Lazennec-Schurdevin, E. Larquet, Y. Mechulam, P.-D. Coureux, E. Schmitt

This study investigates the role of aIF5B in archaeal translation initiation, showing it accelerates subunit joining without GTP hydrolysis and reveals structural interactions with aIF1A.

bioRxiv · May 1, 2022Biochemistry

Adaptive landscape flattening allows the design of both enzyme:substrate binding and catalytic power

V. Opuu, G. Nigro, E. Schmitt, Y. Mechulam, T. Simonson

This paper designs an enzyme to bind transition state analogs using adaptive landscape flattening, achieving accurate predictions of catalytic activity and reaction rates.

bioRxiv · Sep 18, 2019Biochemistry