Author

G. Nigro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

E. Schmitt· 2 shared P. Sansonetti· 2 shared T. Simonson· 2 shared V. Opuu· 2 shared Y. Mechulam· 2 shared A. Doukani· 1 shared A. Gewirtz· 1 shared A. Mettouchi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

E. Schmitt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The oncogenic role of Streptococcus gallolyticus subsp. gallolyticus is linked to activation of multiple cancer-related signaling pathways

E. Pasquereau-Kotula, G. Nigro, F. Dingli, D. Loew, P. Poullet, Y. Xu, S. Kopetz, J. Davis, L. Peduto, C. Robbe-Masselot, P. Sansonetti, P. Trieu-Cuot, S. Dramsi

This study shows that SGG UCN34 promotes colon cancer by activating multiple cancer-related signaling pathways through proteomic and phosphoproteomic analyses in mice and human tumors.

bioRxiv · Feb 17, 2023 · PreprintMicrobiology

Redesigning methionyl-tRNA synthetase for β-methionine activity with adaptive landscape flattening and experiments

V. Opuu, G. Nigro, C. Lazennec, Y. Mechulam, E. Schmitt, T. Simonson

The paper redesigns methionyl-tRNA synthetase to increase activity towards β-methionine using computational protein design and experimental validation.

bioRxiv · Dec 28, 2022Biochemistry

Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells

E. Bergsten, D. Mestivier, F. Donnadieu, T. Pedron, C. Barau, L. Tsoumtsa, A. Mettouchi, E. Lemichez, O. Gorgette, M. Chamaillard, A. Vaysse, S. Volant, A. Doukani, P. J. Sansonetti, I. Sobhani, G. Nigro

This study shows that Parvimonas micra phylotype A alters DNA methylation and gene expression in intestinal epithelial cells, potentially contributing to colorectal cancer.

bioRxiv · May 14, 2022 · PreprintMicrobiology

Adaptive landscape flattening allows the design of both enzyme:substrate binding and catalytic power

V. Opuu, G. Nigro, E. Schmitt, Y. Mechulam, T. Simonson

This paper designs an enzyme to bind transition state analogs using adaptive landscape flattening, achieving accurate predictions of catalytic activity and reaction rates.

bioRxiv · Sep 18, 2019Biochemistry

Innate immune recognition of a bacterial MAMP leads to conditional activation of pro- or anti-inflammatory responses

J. H. Park, S. Cornick, G. Nigro, G. Bertin, F. Dejardin, R. Smits, M. Berard, F. Langa Vives, I. Gomperts Boneca, A. Gewirtz, B. Chassaing, N. Barnich, P. Sansonetti, G. Eberl

This study shows that flagellin, a bacterial MAMP, can trigger either pro- or anti-inflammatory responses depending on the tissue's physiological state and context.

bioRxiv · Jul 28, 2019 · PreprintImmunology