Defunctionalizing Intracellular Organelles with Genetically-Encoded Molecular Tools Based on Engineered Phospholipase A/Acyltransferases (PLAATs)
S. Watanabe, Y. Nihongaki, K. Itoh, S. Watanabe, T. Inoue
The paper introduces PLAATs, engineered phospholipase A/acyltransferases, to rapidly defunctionalize organelles by remodeling membrane phospholipids, demonstrating effectiveness in mitochondria and peroxisomes.
bioRxiv · Oct 10, 2021Cell Biology