Inside and outside of virus-like particles HBc and HBc/4M2e: a comprehensive study of the structure
V. V. Egorov, A. V. Shvetsov, E. B. Pichkur, A. A. Shaldzhyan, Y. A. Zabrodskaya, D. S. Vinogradova, P. A. Nekrasov, A. N. Gorshkov, Y. P. Garmay, A. A. Kovaleva, L. A. Stepanova, L. M. Tsybalova, T. A. Shtam, A. G. Myasnikov, A. L. Konevega
The paper studies the structure of HBc and HBc/4M2e particles using cryo-EM and molecular modeling, showing amyloid-like fibril formation of M2e fragments and a high-resolution model of HBc-4M2e.
bioRxiv · Jul 4, 2022Biophysics