Author

A. G. Myasnikov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 4 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Frost· 2 shared A. A. Anand· 1 shared A. A. Kovaleva· 1 shared A. A. Shaldzhyan· 1 shared A. L. Konevega· 1 shared A. N. Gorshkov· 1 shared A. Palla· 1 shared A. V. Shvetsov· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

A. Frost

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Author profile →

5 papers

Recent·Most cited

Inside and outside of virus-like particles HBc and HBc/4M2e: a comprehensive study of the structure

V. V. Egorov, A. V. Shvetsov, E. B. Pichkur, A. A. Shaldzhyan, Y. A. Zabrodskaya, D. S. Vinogradova, P. A. Nekrasov, A. N. Gorshkov, Y. P. Garmay, A. A. Kovaleva, L. A. Stepanova, L. M. Tsybalova, T. A. Shtam, A. G. Myasnikov, A. L. Konevega

The paper studies the structure of HBc and HBc/4M2e particles using cryo-EM and molecular modeling, showing amyloid-like fibril formation of M2e fragments and a high-resolution model of HBc-4M2e.

bioRxiv · Jul 4, 2022Biophysics

Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance

K. Tsai, V. Stojkovic, L. Noda-Garcia, I. D. Young, A. G. Myasnikov, J. Kleinman, A. Palla, S. N. Floor, A. Frost, J. S. Fraser, D. S. Tawfik, D. Galonic Fujimori

This study uses directed evolution to identify Cfr variants that enhance rRNA methylation, revealing structural insights into antibiotic resistance mechanisms.

bioRxiv · Mar 12, 2021Biochemistry

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

Y. Liu, M. Sun, A. G. Myasnikov, D. Elnatan, N. Delaeter, M. Nguyenquang, D. Agard

The paper determines cryo-EM structures of Hsp90:Aha1 complexes in multiple states to reveal a multistep activation mechanism where Aha1 accelerates ATP hydrolysis and induces conformational changes in Hsp90.

bioRxiv · Jun 30, 2020 · PreprintBiophysics

Allosteric coupling between alpha-rings of the 20S proteasome

Z. Yu, Y. Yu, F. Wang, A. G. Myasnikov, P. Coffino, Y. Cheng

The paper shows that ATPase binding at one end of the 20S proteasome allosterically opens the opposite gate, promoting symmetric and asymmetric proteasome configurations.

bioRxiv · Nov 7, 2019Biochemistry

Structural basis of eIF2B-catalyzed GDP exchange and phosphoregulation by the integrated stress response

A. A. Anand, L. R. Kenner, H. C. Nguyen, A. G. Myasnikov, C. J. Klose, L. A. McGeever, J. C. Tsai, L. E. Miller-Vedam, P. Walter, A. Frost

The paper reports cryoEM structures of eIF2 bound to eIF2B, revealing the mechanism of GDP exchange and phosphoregulation in the integrated stress response.

bioRxiv · Dec 22, 2018Biochemistry