Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease
H. Alhaddad, O. E. Ospina, M. L. Khaled, Y. Ren, P. A. Forsyth, Y. Pina, R. Macaulay, V. Law, K. Y. Tsai, W. D. Cress, B. Fridley, I. Smalley
This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.
bioRxiv · Dec 18, 2023Cancer Biology