Author

O. E. Ospina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:spatial transcriptomics· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

A. C. Soupir· 2 shared B. J. Manley· 2 shared B. L. Fridley· 2 shared H. Alhaddad· 2 shared I. Smalley· 2 shared K. Y. Tsai· 2 shared M. L. Khaled· 2 shared P. A. Forsyth· 2 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

A. C. Soupir

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Author profile →

4 papers

Recent·Most cited

scSpatialSIM: a simulator of spatial single-cell molecular data

A. C. Soupir, J. Wrobel, J. H. Creed, O. E. Ospina, C. M. Wilson, B. J. Manley, L. C. Peres, B. L. Fridley

scSpatialSIM simulates spatial single-cell molecular data to evaluate spatial clustering methods, finding Ripleys K(r) best detects clustering across scenarios.

bioRxiv · Feb 8, 2024Cell Biology

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

M. L. Khaled, Y. Ren, R. Kundalia, H. Alhaddad, Z. Chen, G. C. Wallace, B. Evernden, O. E. Ospina, M. Hall, M. Liu, L. N. F. Darville, V. Izumi, Y. A. Chen, S. Pilon-Thomas, P. A. Stewart, , I. Smalley

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

bioRxiv · Dec 18, 2023 · PreprintCancer Biology

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

H. Alhaddad, O. E. Ospina, M. L. Khaled, Y. Ren, P. A. Forsyth, Y. Pina, R. Macaulay, V. Law, K. Y. Tsai, W. D. Cress, B. Fridley, I. Smalley

This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.

bioRxiv · Dec 18, 2023Cancer Biology

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

A. C. Soupir, M. T. Hayes, T. C. Peak, O. E. Ospina, N. H. Chakiryan, A. E. Berglund, P. A. Stewart, J. V. Nguyen, C. M. M. Segura, N. L. Francis, P. M. R. Echevarria, J. Chahoud, R. Li, K. Y. Tsai, J. A. Blasi, , B. J. Manley

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

bioRxiv · Nov 16, 2023Cancer Biology