Author

K. Y. Tsai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

O. E. Ospina· 2 shared A. Aiderus· 1 shared A. Angarita· 1 shared A. C. Soupir· 1 shared A. d. M. Pulido· 1 shared A. E. Berglund· 1 shared A. L. Meshey· 1 shared A. M. Contreras-Sandoval· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersCancer Biology

O. E. Ospina

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Author profile →

7 papers

Recent·Most cited

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

H. Alhaddad, O. E. Ospina, M. L. Khaled, Y. Ren, P. A. Forsyth, Y. Pina, R. Macaulay, V. Law, K. Y. Tsai, W. D. Cress, B. Fridley, I. Smalley

This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.

bioRxiv · Dec 18, 2023Cancer Biology

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

A. C. Soupir, M. T. Hayes, T. C. Peak, O. E. Ospina, N. H. Chakiryan, A. E. Berglund, P. A. Stewart, J. V. Nguyen, C. M. M. Segura, N. L. Francis, P. M. R. Echevarria, J. Chahoud, R. Li, K. Y. Tsai, J. A. Blasi, , B. J. Manley

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

bioRxiv · Nov 16, 2023Cancer Biology

The OSUMMER lines: a series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6

B. M. Murphy, D. M. Jensen, T. E. Arnold, R. Aguilar Valenzuela, J. Hughes, V. Posada, K. T. Nguyen, V. T. Chu, K. Y. Tsai, C. J. Burd, C. E. Burd

The paper introduces a series of NRAS-mutant melanoma cell lines derived from UV-exposed mice to model human melanoma resistance and therapy responses.

Pigment Cell & Melanoma Research · Sep 1, 2023Peer-reviewedCancer Biology

Microbiome modulates immunotherapy response in cutaneous squamous cell carcinoma

A. Y. Voigt, A. Walter, K. Prieto, A. d. M. Pulido, B. M. B. Bittencourt, T. Young, J. P. Graham, K. Y. Tsai, J. P. Sundberg, J. Oh

This study shows that the skin microbiome affects the response to anti-PD1 immunotherapy in squamous cell carcinoma by using antibiotic-induced microbiome depletion in mice.

bioRxiv · Jan 25, 2023Microbiology

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma

A. Srivastava, C. Tommasi, D. Sessions, A. Mah, T. Bencomo, J. M. Garcia, T. Jiang, M. Lee, J. Y. Shen, L. W. Seow, A. Nguyen, K. Rajapakshe, C. Coarfa, K. Y. Tsai, V. Lopez-Pajares, C. S. Lee

This study identifies RET activation driven by MAB21L4-CacyBP interaction as a driver of squamous cell carcinoma and shows RET inhibition as a potential therapeutic strategy.

bioRxiv · Jan 19, 2022 · PreprintCancer Biology

MAPK-induced miR-29 targets MAFG and suppresses melanoma development

O. Vera, I. Bok, N. Jasani, K. Nakamura, X. Xu, N. Mecozzi, A. Angarita, K. Wang, K. Y. Tsai, F. A. Karreth

This study shows that MAPK-induced miR-29 suppresses melanoma by targeting MAFG, and its inactivation accelerates tumor development.

bioRxiv · Jan 27, 2020Cancer Biology

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

A. Aiderus, J. Y. Newberg, L. Guzman-Rojas, A. M. Contreras-Sandoval, A. L. Meshey, D. J. Jones, F. Amaya-Manzanares, R. Rangel, J. M. Ward, S. C. Lee, K. H.-K. Ban, K. Rogers, S. M. Rogers, L. Selvanesan, L. A. McNoe, , M. B. Mann

This study uses transposon mutagenesis to identify genetic drivers of keratinocyte transformation and cutaneous squamous cell carcinoma progression in vivo, revealing both known and novel genes involved in the disease.

bioRxiv · Dec 24, 2019Cancer Biology