H. Tian

Interpretable Atomistic Prediction and Functional Analysis of Conformational Ensembles and Allosteric States in Protein Kinases Using AlphaFold2 Adaptation with Randomized Sequence Scanning and Local Frustration Profiling

This study adapts AlphaFold2 to predict conformational ensembles and allosteric states of ABL kinase using sequence scanning and frustration profiling, revealing limitations in detecting low-populated inactive states.

Association of poultry vaccination with the interspecies transmission and molecular evolution of H5 subtype avian influenza virus

This study examines how poultry vaccination affects H5 avian influenza virus transmission and evolution, finding increased nonsynonymous divergence in vaccinated poultry lineages.

How to barcode (almost all) freshwater biodiversity

This study identifies cost-effective primer pairs and develops a tool to enhance eDNA-based monitoring of freshwater biodiversity.

Synchrony of Bird Migration with Avian Influenza Global Spread; Implications for Vulnerable Bird Orders

The paper uses phylodynamic analyses to link bird migration patterns with the global spread of HPAIV H5 clade 2.3.4.4, identifying vulnerable bird orders and highlighting Suliformes and Ciconiiformes as important in virus dispersal.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Prion-like characteristics of Hepatitis E virus ORF3 protein are associated with virus release and pathogenesis

This study identifies HEV-ORF3 as a prion-like protein that facilitates virion release and pathogenesis by forming filamentous structures, highlighting its role in viral assembly.

Probing Conformational Landscapes and Mechanisms of Allosteric Communication in the Functional States of the ABL Kinase Domain Using Multiscale Simulations and Network-Based Mutational Profiling of Allosteric Residue Potentials

This study uses multiscale simulations and network-based mutational profiling to analyze conformational dynamics and allosteric communication in the ABL kinase domain, identifying key regulatory hotspots.

Complexes Formed by Mixing Tumor-derived Extracellular Vesicles with Polymeric Surfactants for Personalized Therapeutic Vaccine

This paper develops a therapeutic vaccine using tumor-derived extracellular vesicles modified with polymeric surfactants to enhance immunogenicity and efficacy against melanoma.

Multimodal mass spectrometry imaging reveals single-cell metabolic states in mammalian liver

This paper develops a multimodal mass spectrometry imaging workflow to classify liver cell types and metabolic zones at single-cell resolution in human tissue.

Strong and consistent associations of waterbird community composition with HPAI H5 occurrence in European wild birds

The paper shows that waterbird community composition strongly predicts HPAI H5 occurrence in wild birds across different epidemics, with similar patterns observed for H5N8 and H5N1.

Topological action potentials in engineered tissues

The paper demonstrates that gap junction-coupled interfaces between non-excitable tissues can exhibit electrical excitability, a topologically protected phenomenon with broader ion channel expression tolerance than bulk excitability.

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.

Entry Pathway for the Inverse Agonist Ligand in the G Protein-Coupled Receptor Rhodopsin

This study investigates the pathway for 11-cis-retinal entry into rhodopsin, finding that it enters through a transmembrane channel between TM5/6, controlled by dynamic allosteric mechanisms.

Arabidopsis CALMODULIN-BINDING PROTEIN 60b plays dual roles in plant immunity

This study shows CBP60b positively regulates SNC2-mediated immunity in Arabidopsis by enhancing SARD1 expression and is required for TIR signaling.

SUMOylation of GMFB regulates the stability and function of GMF in RPE cells under oxidative stress and inflammation

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

Outer membrane vesicles derived from Salmonella Typhimurium can deliver Shigella flexneri 2a O-polysaccharide antigen to prevent lethal pulmonary infection in mice

This study develops an OMV-based vaccine using Salmonella Typhimurium to deliver Shigella flexneri 2a O-polysaccharide antigen, showing protection against lethal pulmonary infection in mice.

Activation of TIR signaling is required for pattern-triggered immunity

This study shows that TIR signaling is essential for enhancing plant defense during pattern-triggered immunity by activating defense genes and increasing resistance to pathogens.

The glycosyltransferase UGT76B1 is critical for plant immunity as it governs the homeostasis of N-hydroxy-pipecolic acid

This paper identifies UGT76B1 as a glycosyltransferase critical for plant immunity by regulating N-hydroxy-pipecolic acid homeostasis, linking its metabolism to defense and growth trade-offs.

Three LysM effectors of Zymoseptoria tritici collectively disarm chitin-triggered plant immunity

This study identifies three LysM effectors in Zymoseptoria tritici that suppress chitin-triggered wheat immunity by binding chitin, inhibiting ROS production, and protecting fungal hyphae from chitinase.

Fungal dual-domain LysM effectors undergo chitin-induced intermolecular, and not intramolecular, dimerization

This study shows that fungal dual-domain LysM effectors form intermolecular rather than intramolecular dimers upon chitin binding, leading to lower affinity compared to Ecp6 but enabling polymer formation.

The therapeutic effects of intratumoral injection of IL12IL2GMCSF fusion protein on canine tumors

This study evaluates the therapeutic effects of IL12IL2GMCSF fusion protein in canine tumors, showing significant response rates with minimal adverse effects.

Dexmedetomidine mediates microRNA-185 to suppress ovarian cancer growth via inhibiting the SOX9/Wnt/β-catenin signaling pathway

This study identifies HAND2-AS1 as a tumor suppressor in cervical cancer by regulating miR-21 and ALEX1 to inhibit proliferation and EMT.

Reconstruction and dynamics of human intestinal microbiome observed in situ

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

Domain segregated 3D chromatin structure and segmented DNA methylation in carcinogenesis

The paper examines how 3D chromatin structure and DNA methylation change in cancer, showing increased segregation of chromatin domains and methylation differences that correlate with transcriptional changes.

A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization

The paper identifies Mg1LysM's role in forming chitin-dependent and independent homodimers, which protect fungal cell walls from host chitinase hydrolysis.

The glycine locating at random coil of picornaviruses VP3 enhances viral pathogenicity by targeting p53 to promote apoptosis and autophagy

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.

High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Co-receptor CCR5

The paper develops a fluorescence assay to study high-affinity chemokine analogs that show ligand bias at CCR5, finding they bind with subnanomolar affinities and occupy a site not accessible to native chemokines.

PRH1 mediates ARF7-LBD dependent auxin signaling to regulate lateral root development in Arabidopsis thaliana

This study identifies PRH1 as a target of ARF7 and LBDs in auxin signaling, showing its role in lateral root development through interaction with GATA23.

CXXC1 is redundant for normal DNA double-strand break formation and meiotic recombination in mouse

This study shows that CXXC1 is not essential for meiotic recombination in mice, as its loss does not affect DNA double-strand break formation or repair.