BiochemistrybioRxivPreprint
The P3 O-Tert-Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors
Y. Ma, K. Yang, Z. Z. Geng…·W. R. Liu
This study identifies O-tert-butyl-threonine at the P3 site as critical for enhancing cellular and antiviral potency of MPro inhibitors.
DOI 10.1101/2021.12.18.473326