Author

C.-C. Cho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:virus· 2 Assay:proteomics· 1

Frequent Co-Authors

S. Xu· 6 shared W. R. Liu· 6 shared E. C. Vatansever· 5 shared K. Khatua· 4 shared Y. Ma· 4 shared Z. Z. Geng· 4 shared G. Yu· 3 shared H. Ji· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersBiochemistry

S. Xu

Mutual co-authors in cluster

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6 papers

Recent·Most cited

An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease

K. Khatua, Y. R. Alugubelli, K. Yang, V. Reddy, L. Blankenship, D. Coleman, S. Atla, S. Chaki, Z. Geng, X. Ma, J. Xiao, P.-H. Chen, C.-C. Cho, E. C. Vatansever, Y. Ma, , W. R. Liu

This study develops an azapeptide platform with covalent warheads to identify potent SARS-CoV-2 MPro inhibitors, including MPI89 with a 10 nM EC50 and high selectivity.

bioRxiv · Apr 11, 2023 · PreprintBiochemistry

A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

Z. Z. Geng, S. Atla, N. Shaabani, V. R. Vulupara, K. S. Yang, Y. R. Alugubelli, K. Khatua, P.-H. C. Chen, J. Xiao, L. R. Blankenship, X. R. Ma, E. C. Vatansever, C.-C. Cho, Y. Ma, R. Allen, , W. R. Liu

This study systematically evaluates dipeptidyl inhibitors of SARS-CoV-2 main protease, identifying compounds with high antiviral potency and low cytotoxicity.

bioRxiv · Jan 17, 2023Biochemistry

An Amber-Encoding Helper Phage for More Efficient Phage Display of Noncanonical Amino Acids

J. T. Hampton, C.-C. Cho, Z. Z. Geng, D. D. Coleman, P.-H. C. Chen, G. K. Dubey, L. D. Sylvain, S. Xu, W. R. Liu

This paper introduces a novel helper phage, CMa13ile40, that improves the efficiency of phage display by enabling rapid enrichment of amber codon-containing phage clones and enhancing the production of noncanonical amino acid (ncAA)-containing phages.

bioRxiv · Dec 19, 2022Biochemistry

The N-Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

Y. R. Alugubelli, Z. Z. Geng, K. Yang, N. Shaabani, K. Khatua, X. R. Ma, E. C. Vatansever, C.-C. Cho, Y. Ma, L. Blankenship, G. Yu, B. Sankaran, P. Li, R. Allen, H. Ji, , W. R. Liu

This paper identifies that a P4 N-terminal carbamate in boceprevir-based inhibitors is crucial for high antiviral potency against SARS-CoV-2.

bioRxiv · Dec 18, 2021 · PreprintBiochemistry

The P3 O-Tert-Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors

Y. Ma, K. Yang, Z. Z. Geng, Y. R. Alugubellia, N. Shaabani, E. C. Vatansever, X. R. Ma, C.-C. Cho, K. Khatua, L. Blankenship, G. Yu, B. Sankaran, P. Li, R. Allen, H. Ji, , W. R. Liu

This study identifies O-tert-butyl-threonine at the P3 site as critical for enhancing cellular and antiviral potency of MPro inhibitors.

bioRxiv · Dec 18, 2021 · PreprintBiochemistry

Bepridil is Potent Against SARS-CoV-2 In Vitro

E. C. Vatansever, K. S. Yang, K. C. Kratch, A. Drelich, C.-C. Cho, D. M. Mellott, S. Xu, C.-T. K. Tseng, W. R. Liu

This study identifies bepridil as a potent inhibitor of SARS-CoV-2 MPro and virus entry, showing efficacy in vitro at low concentrations.

bioRxiv · May 23, 2020Pharmacology & Toxicology