H. Ji

An AINTEGUMENTA phospho-switch controls bilateral stem cell activity during secondary growth

This paper identifies a phosphorylation mechanism controlled by the ERECTA receptor and auxin signaling that regulates stem cell activity and vascular cell differentiation in plants.

Macroscopic label-free biomedical imaging withshortwave infrared Raman scattering

This paper introduces a shortwave infrared Raman imaging technique that enables label-free, high-contrast visualization of tissue composition and pathology without contrast agents.

Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.

This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

Efficient differentiation of human retinal pigment epithelium cells from chemically induced pluripotent stem cells

This study develops a chemical method to generate hCiPSCs and demonstrates their efficient differentiation into RPE cells for AMD treatment.

Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

The paper introduces MEMORY, a method to identify GEARs associated with cancer prognosis, finding mitosis-related genes in LUAD and immunity-related genes in BRCA.

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia

This study shows that SARS-CoV-2 N protein reduces Dicer, XPO5, SRSF3, and hnRNPA3, leading to pneumonia, and that inhibitors can reverse this effect.

A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

The paper identifies a 26-gene expression signature in high-risk gastric intestinal metaplasia (GIM) that localizes to intestinal stem-like cells and is associated with increased gastric cancer risk.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-β signaling.

This study identifies heparan sulfate modifications as critical for betaglycan ectodomain shedding, which regulates TGF-β signaling and has clinical implications in ovarian cancer.

CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1-mutant lung cancer

The paper identifies CD38 as a therapeutic target in LKB1-mutant lung cancer through in vivo metabolomics and shows that targeting CD38 inhibits tumor growth.

Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm rupture

This study uses single-cell transcriptomics to analyze human intracranial aneurysm tissue, identifying immune cell features linked to aneurysm rupture.

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancers

The paper examines GITR and TIGIT immunotherapies in gastrointestinal cancers using ex vivo cultures and single-cell sequencing to identify their cellular mechanisms in the tumor microenvironment.

Mutagenic-end joining results in smaller deletions in heterochromatin relative to euchromatin

The paper investigates repair mechanisms in Drosophila heterochromatin and euchromatin, finding that heterochromatin favors HR over mutagenic EJ, leading to smaller deletions via SD-MMEJ.

Development of a human glioblastoma model using humanized DRAG mice for immunotherapy

This study develops a humanized DRAG mouse model to test GBM immunotherapy, showing anti-PD-1 antibodies reduce immunosuppressive cells in xenografted tumors.

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

This study systematically evaluates dipeptidyl inhibitors of SARS-CoV-2 main protease, identifying compounds with high antiviral potency and low cytotoxicity.

Inspiration of SARS-CoV-2 envelope protein mutations on pathogenicity of Omicron XBB

The paper analyzes SARS-CoV-2 envelope protein mutations across Omicron sub-variants to assess their impact on pathogenicity, finding that certain mutations correlate with reduced disease severity.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

A robotic system for automated genetic manipulation and analysis of Caenorhabditis elegans

This paper introduces a robotic system for automated genetic manipulation of C. elegans, demonstrating reliability and throughput comparable to manual methods.

Limited Defense of Liver Energy Status in Rats Susceptible to Diet-induced Obesity

This study shows that rats susceptible to diet-induced obesity have impaired liver energy status recovery during refeeding, linked to increased food intake.

Chimeric mRNA based COVID-19 vaccine induces protective immunity against Omicron and Delta

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters.

The paper identifies a mutation in the SARS-CoV-2 Omicron variant's structural envelope protein that reduces ion channel calcium permeability and acid sensitivity, leading to lower cell damage and cytokine production.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Single-cell RNA-seq analysis reveals lung epithelial cell-specific contributions of Tet1 to allergic inflammation

This study uses single-cell RNA-seq to show that Tet1 deletion in lung epithelial cells promotes allergen-induced inflammation by altering transcriptomic networks and cell type composition.

The N-Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

This paper identifies that a P4 N-terminal carbamate in boceprevir-based inhibitors is crucial for high antiviral potency against SARS-CoV-2.