Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site
S. Lacham-Hartman, Y. Shmidov, E. Radisky, R. B. Bitton, D. Lukatsky, N. Papo
The paper demonstrates avidity in a bivalent inhibitor interacting with a monomeric enzyme, showing enhanced binding affinity through cooperative binding despite the absence of receptor clustering.
bioRxiv · Mar 23, 2021Biochemistry