E. Radisky

Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension

This study extends the plasma half-life of N-TIMP2 by appending a PATylated tail, showing improved therapeutic potential in mice.

Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site

The paper demonstrates avidity in a bivalent inhibitor interacting with a monomeric enzyme, showing enhanced binding affinity through cooperative binding despite the absence of receptor clustering.