Extracellular DJ-1 induces sterile inflammation in the ischemic brain
K. Nakamura, S. Sakai, J. Tsuyama, A. Nakamura, K. Otani, K. Kurabayashi, Y. Yogiashi, H. Masai, T. Shichita
This paper shows that extracellular DJ-1 triggers inflammation in ischemic brains by activating TLR2 and TLR4, and that blocking DJ-1 reduces inflammation and neuronal damage.
bioRxiv · Sep 16, 2020Immunology