S. Sakai

Parallel rapid phenotypic differentiation along climatic gradients in multiple introduced lineages of an alien plant species

The paper examines phenotypic differentiation in three lineages of Cardamine hirsuta introduced to Japan, finding parallel clinal patterns related to climate factors.

Sustaining microglial reparative function enhances stroke recovery

This study identifies ZFP384 as a regulator that impairs microglial reparative function after stroke, and shows that targeting ZFP384 enhances recovery even in the chronic phase.

Development of a rapid and highly accurate method for 13C tracer-based metabolomics and its application on a hydrogenotrophic methanogen

The paper develops a CE-MS method for 13C tracer-based metabolomics and applies it to identify central carbon metabolism and amino acid biosynthesis in a methanogen.

IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques

This study examines the roles of IFNγ and IL-10 in SARS-CoV-2 infection of rhesus macaques, finding IL-10 suppresses T cell expansion but promotes tissue-resident memory cell formation.

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

This study shows that SARS-CoV-2 replication declines in the lungs before T cell responses, while innate immunity restricts viral replication in nasal and oral mucosa in rhesus macaques.

Sequestration and efflux largely account for cadmium and copper resistance in the deep sea epsilonproteobacterium Nitratiruptor sp. SB155 2

This study investigates metal resistance mechanisms in Nitratiruptor sp. SB155-2 by analyzing transcriptomic and morphological responses to cadmium and copper stress.

Are microbes growing on flowers evil? Effects of old flower microbes on fruit set in a wild ginger with one-day flowers, Alpinia japonica (Zingiberaceae)

The study investigates whether microbes from old flowers negatively impact fruit set in Alpinia japonica by inoculating new flowers with old flower microbes and analyzing microbial communities.

Eosinophils are an integral component of the pulmonary granulocyte response in Tuberculosis and promote host resistance in mice

This study shows eosinophils are recruited to tuberculosis-infected lung tissue in mice and contribute to host resistance against Mtb infection.

Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

This study shows that 5-OP-RU treatment of M. tuberculosis-infected rhesus macaques leads to MAIT cell dysfunction rather than expansion, with upregulated PD-1 and loss of cytokine production.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

Extracellular DJ-1 induces sterile inflammation in the ischemic brain

This paper shows that extracellular DJ-1 triggers inflammation in ischemic brains by activating TLR2 and TLR4, and that blocking DJ-1 reduces inflammation and neuronal damage.

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.

Maintenance of High Inbreeding Depression in Selfing Populations: Effects of Coupling of Early- and Late-Acting Mutations

The paper develops a simulation model showing that coupling early- and late-acting mutations maintains inbreeding depression in selfing populations.

Isolation of an archaeon at the prokaryote-eukaryote interface

The paper isolates an Asgard archaeon and proposes a symbiosis model for eukaryogenesis based on its morphology and metabolism.

Dynamic and synergistic influences of air temperature and rainfall on general flowering in a Bornean lowland tropical forest

The paper analyzes 17 years of phenology data from a Bornean tropical forest to show that general flowering is driven by cumulative cool temperature and drought, with changing relationships over time.