Author

Y.-C. Chien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Assay:cryo-EM· 1 Assay:proteomics· 1

Frequent Co-Authors

K.-H. Khoo· 2 shared P.-Y. Yu· 2 shared S.-T. D. Hsu· 2 shared T.-J. Yang· 2 shared B. Lin· 1 shared C.-W. Kuo· 1 shared H.-C. Wu· 1 shared K.-H. Liang· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiophysics

K.-H. Khoo

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structure-activity relationships of B.1.617 and other SARS-CoV-2 spike variants

T.-J. Yang, P.-Y. Yu, Y.-C. Chang, N.-E. Chang, Y.-X. Tsai, K.-H. Liang, P. Draczkowski, B. Lin, Y.-S. Wang, Y.-C. Chien, K.-H. Khoo, H.-C. Wu, S.-T. D. Hsu

This study reports cryo-EM structures of SARS-CoV-2 spike variants and finds mutations alter conformation and glycan shield, enhance ACE2 binding, but are neutralized by three antibodies.

bioRxiv · Sep 12, 2021 · PreprintBiophysics

Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variants

C.-W. Kuo, T.-J. Yang, Y.-C. Chien, P.-Y. Yu, S.-T. D. Hsu, K.-H. Khoo

The paper analyzes site-specific glycosylation changes in SARS-CoV-2 spike proteins of D614G and Alpha variants, revealing altered N-glycan processing and potential impacts on transmissibility.

bioRxiv · Jul 21, 2021Biochemistry