T.-J. Yang

Targeting Reductive Metabolic Shifts by T315I Mutation in BCR-ABL Myeloid Leukemia for Therapy

This study identifies metabolic shifts in T315I-Bcr-Abl CML and shows that combining JMF4073 with UK-5099 eradicates the disease in vivo.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

Structure-activity relationships of B.1.617 and other SARS-CoV-2 spike variants

This study reports cryo-EM structures of SARS-CoV-2 spike variants and finds mutations alter conformation and glycan shield, enhance ACE2 binding, but are neutralized by three antibodies.

Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variants

The paper analyzes site-specific glycosylation changes in SARS-CoV-2 spike proteins of D614G and Alpha variants, revealing altered N-glycan processing and potential impacts on transmissibility.

Impacts on the structure-function relationship of SARS-CoV-2 spike by B.1.1.7 mutations

This study examines how B.1.1.7 mutations affect the structure and function of SARS-CoV-2 spike protein, showing changes in receptor binding and antibody neutralization.

COVID-19 dominant D614G mutation in the SARS-CoV-2 spike protein desensitizes its temperature-dependent denaturation

The paper shows the D614G mutation in SARS-CoV-2 spike protein increases thermal stability and reduces cold-induced unfolding, enhancing viral infectivity.

Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2

This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.

Multiple reference genome sequences of hot pepper reveal the massive evolution of plant disease resistance genes by retroduplication

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.