Author

Y.-W. Kuo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. Howard· 5 shared M. S. S. Mahamdeh· 2 shared A. Luchniak· 1 shared B. W. Falk· 1 shared C. McGuinness· 1 shared F. Hu· 1 shared J. C. Nigg· 1 shared K. Zhang· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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5 shared papersBiophysics

J. Howard

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Dynamic microtubules slow down during their shrinkage phase

A. Luchniak, Y.-W. Kuo, C. McGuinness, S. Sutradhar, R. Orbach, M. S. S. Mahamdeh, J. Howard

This study shows that microtubule shrinkage slows over time after catastrophe, indicating a multi-state process similar to the growing phase.

bioRxiv · Jul 27, 2022Biophysics

The force required to remove tubulin from the microtubule lattice

Y.-W. Kuo, M. S. S. Mahamdeh, Y. Tuna, J. Howard

The paper measures the force required to remove tubulin from microtubules and identifies partial unfolding as an intermediate step in the process.

Nature Communications · Jun 25, 2022Peer-reviewedBiophysics

Counting fluorescently labeled proteins in tissues in the spinning disk microscope using single-molecule calibrations

M. Liao, Y.-W. Kuo, J. Howard

The paper develops a calibration technique for spinning-disk confocal microscopy to count fluorescent proteins in tissues, enabling accurate quantification of molecular numbers and concentrations.

bioRxiv · Jan 2, 2022Biophysics

Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism

Q. Rao, Y. Wang, P. Chai, L. Han, Y.-W. Kuo, R. Yang, F. Hu, Y. Yang, J. Howard, K. Zhang

The paper determines high-resolution structures of outer-arm dynein arrays bound to microtubule doublets, revealing a mechanism for motor coordination through ATP hydrolysis and tail-to-head interactions.

bioRxiv · Dec 8, 2020 · PreprintCell Biology

Endogenous viral element-derived piRNAs are not required for production of ping-pong-dependent piRNAs from Diaphorina citri densovirus

J. C. Nigg, Y.-W. Kuo, B. W. Falk

The paper shows that DcDV-derived EVEs are not required for ping-pong-dependent vpiRNA production against DcDV in D. citri, but vpiRNAs target DcDV in EVE-lacking individuals.

bioRxiv · May 20, 2020Microbiology

Predicted effects of severing enzymes on the length distribution and total mass of microtubules

Y.-W. Kuo, J. Howard, O. Trottier

The paper develops a mathematical model to explain how severing enzymes affect microtubule length distribution and mass, showing severing rate and growth speed determine steady-state length distribution and amplify microtubule mass.

bioRxiv · Aug 30, 2019Biophysics