Intratumoral amino acid insufficiency limits CD8+ T-cell effector function
Yanting Chen, Ya Hui Lin, Jahan A. Rahman, Justin R. Cross, Natalya N. Pavlova, Santosha Adipudi Vardhana
This study shows that limited amino acid availability in tumors impairs CD8+ T-cell cytotoxic function by reducing protein synthesis, and demonstrates strategies to restore this function.
bioRxiv · Apr 28, 2025 · PreprintImmunology