Author

Yanting Chen

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-5156-3845Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yanting Chen2 papers · Guangdong Medical College

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Jahan A. RahmaniD· 2 shared Santosha Adipudi VardhanaiD· 2 shared A. Ari HakimiiD· 1 shared Beatrice D. ZhangiD· 1 shared Cameron G. RobertsiD· 1 shared Charlotte R. WayneiD· 1 shared Christopher Austin KlebanoffiD· 1 shared Ekaterina V. VinogradovaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Jahan A. RahmanORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 2, 2026

✦ In-depth digest

Cysteine reactivity profiling links metabolic rewiring to the dysfunctional human T cell proteome.

Hiroyuki Kojima, Charlotte R. Wayne, Luis F. Somarribas Patterson…·Ekaterina V. Vinogradova

In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.

1 citation

ImmunologybioRxivPreprintApr 28, 2025

Intratumoral amino acid insufficiency limits CD8+ T-cell effector function

Yanting Chen, Ya Hui Lin, Jahan A. Rahman…·Santosha Adipudi Vardhana

This study shows that limited amino acid availability in tumors impairs CD8+ T-cell cytotoxic function by reducing protein synthesis, and demonstrates strategies to restore this function.

DOI 10.1101/2025.04.28.651077

humanproteomics