Modeling Compound Lipid Homeostasis Using Stable Isotope Tracing
Karl A. Wessendorf-Rodriguez, Maureen L. Ruchhoeft, Christopher W. Murray, Yale Huang, Ethan L. Ashley, Hector M. Galvez, Grace H. McGregor, Shrikaar Kambhampati, Reuben J. Shaw, Christian M. Metallo
This study introduces CL-MFA to quantify lipid metabolic fluxes in NSCLC models, revealing LKB1 regulation of sphingolipid recycling and fatty acid synthase upregulation under standard culture conditions.
Cell Metabolism · Feb 20, 2026Peer-reviewedCell Biology