Christopher W. Murray

This study introduces CL-MFA to quantify lipid metabolic fluxes in NSCLC models, revealing LKB1 regulation of sphingolipid recycling and fatty acid synthase upregulation under standard culture conditions.

The paper investigates functional differences between EML4-ALK variants V1 and V3 in lung cancer using mouse models and human data, showing variant-specific effects on tumorigenesis.