Grace H. McGregor

This study introduces CL-MFA to quantify lipid metabolic fluxes in NSCLC models, revealing LKB1 regulation of sphingolipid recycling and fatty acid synthase upregulation under standard culture conditions.

This study shows p53 enables lipid headgroup recycling during senescence by increasing phosphoethanolamine supply through autophagy and lysosomal catabolism, revealing a metabolic vulnerability in p53-activated cells.

This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.

The paper develops a method to quantify acyl-chain diversity in isobaric compound lipids using UHPLC-MS and validates it with metabolically engineered adipocytes.