Author

Yali Lai

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Fei XuiD· 1 shared Heng LiuiD· 1 shared Hong ShaniD· 1 shared JING WANG· 1 shared Jingjing HouiD· 1 shared Junrui Li· 1 shared Wen HuiD· 1 shared Xinyue ZhangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Fei XuORCID

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1 paper

Recent·Most cited

Cooperative Peripheral CB1 Inhibition by Extracellular Antibody Binding and Orthosteric Antagonism

YUAN GAO, JING WANG, Yali Lai, Hong Shan, Yue Yang, Yuxin Bai, Jingjing Hou, Junrui Li, Wen Hu, Xinyue Zhang, Yinshan Tang, Fei Xu, Heng Liu

This study reports cryo-EM structures of CB1 bound to Nimacimab and orthosteric antagonists, revealing extracellular allosteric inhibition as a mechanism for peripheral CB1 inhibition.

bioRxiv · Oct 1, 2026 · PreprintPharmacology & Toxicology