Yuan Gao

Seesaw configuration of the ODC-OAZ1-AZIN1 axis governs sensitivity to polyamine-targeting inhibitors of breast cancer cells

This study identifies a seesaw configuration of the ODC-OAZ1-AZIN1 axis that determines breast cancer cell sensitivity to polyamine-targeting inhibitors, offering a framework for personalized therapy.

An iris-like pore for protein import into peroxisomes

The paper reports the structure of a peroxisomal import channel and shows how it adapts to transport proteins of different sizes.

Cooperative Peripheral CB1 Inhibition by Extracellular Antibody Binding and Orthosteric Antagonism

This study reports cryo-EM structures of CB1 bound to Nimacimab and orthosteric antagonists, revealing extracellular allosteric inhibition as a mechanism for peripheral CB1 inhibition.

Ancient tandem duplication of CYCLOIDEA is associated with the evolution of capitulum development in Asteraceae

The paper identifies a conserved CYC2 gene cluster in Asteraceae and shows its evolutionary divergence and expression patterns are linked to capitulum development.

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespan

Reprocessing nine human brain datasets (2,157,582 cells, 156 donors, GW6 to adulthood) under one marker-based taxonomy yields 35 replicable cell types with cell type-specific timing of adult-like maturation.

An integrative single-cell and spatial transcriptomics atlas highlights candidate regulatory factors in the development of gerbera capitulum

The paper develops an integrative single-cell and spatial transcriptomics atlas of Gerbera capitulum development, identifying candidate regulatory factors like GAGL12 involved in vasculature development.

Cryo-EM elucidation of stoichiometric plasticity, asymmetric ligand recognition and allosteric coupling in human P2X2/3 heterotrimeric channels

The paper reports cryo-EM structures of human P2X2/3 heterotrimers in different functional states, revealing asymmetric ligand recognition and allosteric coupling mechanisms.

CombinGym: a benchmark platform for machine learning-assisted design of combinatorial protein variants

CombinGym benchmarks machine learning for combinatorial protein variant design using curated datasets and evaluates model performance across multiple tasks and data splits.

Ultra-precision deconvolution of spatial transcriptomics decodes immune heterogeneity and fate-defining programs in tissues

The paper introduces UCASpatial, an ultra-precision spatial transcriptomics deconvolution algorithm, to improve the identification of immune cell subpopulations and their functional roles in tissue microenvironments.

MEST inhibits ciliary sphingomyelin synthesis to promote tendon stem/progenitor cells osteochondrogenesis in traumatic heterotopic ossification

This study identifies MEST's role in promoting tHO by inhibiting ciliary sphingomyelin synthesis and enhancing Hh signaling in TSPCs.

Cryo-EM reveals the structural basis of subtype-specific, noncompetitive inhibition of the human P2X3 receptor

The paper reports the cryo-EM structure of the human P2X3 receptor complexed with sivopixant, revealing subtype-specific allosteric inhibition mechanisms and structural basis for improved selectivity.

Single-cell molecular subtyping reveals novel intratumor heterogeneity in human Basal-like breast cancer

The paper introduces UBS93, a computational framework for single-cell molecular subtyping, revealing coexistence of Basal-like and Claudin-low subtypes in human Basal-like breast cancer.

Whole-genome sequencing of an advanced case of small-cell gallbladder neuroendocrine carcinoma

This study performs whole-genome sequencing on an advanced case of small-cell gallbladder neuroendocrine carcinoma to identify genetic alterations and potential biomarkers.