Author

Hong Shan

Chinese Academy of SciencesORCID 0000-0003-3572-8774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Organism:human· 1

Frequent Co-Authors

Canrong Wu· 1 shared Fei XuiD· 1 shared H. Eric XuiD· 1 shared He Qian· 1 shared Heng LiuiD· 1 shared JING WANG· 1 shared Jingjing HouiD· 1 shared Junrui Li· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Canrong Wu

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintOct 1, 2026

Cooperative Peripheral CB1 Inhibition by Extracellular Antibody Binding and Orthosteric Antagonism

YUAN GAO, JING WANG, Yali Lai…·Heng Liu

This study reports cryo-EM structures of CB1 bound to Nimacimab and orthosteric antagonists, revealing extracellular allosteric inhibition as a mechanism for peripheral CB1 inhibition.

DOI 10.64898/2026.09.26.754614

humanprotein structure

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Molecular BiologyCell DiscoveryPeer-reviewedMay 6, 2024

Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors

He Qian, Qingning Yuan, Hong Shan…·Lihua Zhao

This study presents cryo-EM structures of MCH-activated MCHR1 and MCHR2 with G-proteins, revealing ligand recognition mechanisms and activation pathways.

14 citations

protein structureexperimental assay

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