Xinyue Zhang

This study reports cryo-EM structures of CB1 bound to Nimacimab and orthosteric antagonists, revealing extracellular allosteric inhibition as a mechanism for peripheral CB1 inhibition.

The paper identifies TAAR1 agonists with antipsychotic-like effects through computational screening and experimental validation, showing improved potency and reduced side effects in a schizophrenia model.

The paper defines the molecular mechanism of graded activation of the dopamine D1 receptor and shows how ligand efficacy is encoded through an activation pathway.

This study determines the cryo-EM structures of OXGR1 bound to metabolites, revealing conserved mechanisms for metabolite recognition and receptor activation.