Spatiotemporal limits of optogenetic manipulations in cortical circuits
Nuo Li, Susu Chen, Zengcai V. Guo, Han Chen, Yan Huo, H. Inagaki, Courtney Davis, David Hansel, Caiying Guo, Karel Svoboda
The paper benchmarks optogenetic silencers in mice to assess their spatial and temporal effects on cortical circuits, finding that photoinhibition extends beyond light spread and can produce paradoxical effects.
bioRxiv · May 21, 2019 · PreprintNeuroscience