Zengcai V. Guo

The paper introduces COMET, a lightweight head-mounted mesoscope for cortex-wide single-cell calcium imaging in freely moving mice, demonstrating its ability to capture neural activity during natural behaviors.

This study identifies the rostro-lateral posterior parietal cortex as a hub that links tactile stimuli to delayed licking during sensorimotor learning, showing its role in maintaining temporal continuity through sustained activity and neural coupling.

This study shows how task congruence affects neural coding geometry and population dynamics in mouse ALM, linking rule-switching complexity to cognitive flexibility.

This paper develops a red fluorescent calcium indicator, SomaFRCaMPi, which improves neuronal activity imaging accuracy and scale in vivo by reducing neuropil contamination and enhancing signal-to-noise ratio.

This paper introduces a miniaturized mesoscope (SOMM) for high-resolution calcium imaging in freely moving mice, achieving widefield, cellular resolution with robustness against motion artifacts.

This study compares GCaMP-X and GCaMP for long-term Ca2+ imaging in neurons, finding GCaMP-X provides better long-term expression and less cytotoxicity.

The paper shows that during short-term memory tasks, basal ganglia direct and indirect pathways oppositely influence decision-making through coactive regulation of cortical activity.

The paper benchmarks optogenetic silencers in mice to assess their spatial and temporal effects on cortical circuits, finding that photoinhibition extends beyond light spread and can produce paradoxical effects.