An Advanced Humanized Systemic Lupus Erythematosus Model Enables Parallel Profiling of B Cell-Targeted Therapies
Rujie Zhu, Shuai Ding, Deshan Ren, Juan Liang, Shuang Liu, Jialu Fan, Shuhua Yu, Zijian Zhang, C. Yan Cheng, K J Wang, Y R Chen, Yang Hang, Xiaoyun Shang, Yan Li, Li Sun
This study develops a humanized SLE model to compare B cell-targeted therapies, finding UCAR-T provides better renal and autoantibody reduction than TCEs despite higher toxicity.
bioRxiv · Jan 29, 2026 · PreprintImmunology