Author

Yang Huo

Indiana University Indianapolis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Lang LiiD· 2 shared Lijun ChengiD· 2 shared Birkan GökbağiD· 1 shared Daniel G. Stover· 1 shared Enze LiuiD· 1 shared Gregory NagyiD· 1 shared Huanmei WuiD· 1 shared Jeffrey D. ParviniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Lang LiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome Screening

Shuai Shao, Shangjia Li, Yang Huo, Shan Tang, Birkan Gökbağ, Kunjie Fan, Yirui Huang, Lingling Wang, Gregory Nagy, Jeffrey D. Parvin, Daniel G. Stover, Lijun Cheng, Lang Li

This study uses CRISPR-Cas9 and RNAseq to identify novel synthetic lethal targets in TNBC cells resistant to cisplatin/doxorubicin, highlighting potential drug targets for combination therapies.

Cancers · Dec 3, 2025Peer-reviewedCancer Biology

DSCN: double-target selection guided by CRISPR screening and network

Enze Liu, Xue Wu, Lei Wang, Yang Huo, Huanmei Wu, Lang Li, Lijun Cheng

DSCN selects effective target combinations by integrating CRISPR screening data and protein-protein interaction networks, showing high accuracy and speed compared to existing methods.

PLoS Computational Biology · Aug 19, 2022Peer-reviewedBioinformatics