Author

Jeffrey D. Parvin

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteORCID 0000-0001-5616-1928Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:variant effect prediction· 2 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

Gregory NagyiD· 3 shared Arkobrato GuptaiD· 2 shared Dongjun ChungiD· 2 shared Hyeongseon JeoniD· 2 shared Lynn Moreira· 2 shared Olivia Tull· 2 shared Philip N. TsichlisiD· 2 shared Rebecca Presley· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Gregory NagyORCID

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Author profile →

4 papers

Recent·Most cited

Cancer BiologyCancersPeer-reviewedDec 3, 2025

Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome Screening

Shuai Shao, Shangjia Li, Yang Huo…·Lang Li

This study uses CRISPR-Cas9 and RNAseq to identify novel synthetic lethal targets in TNBC cells resistant to cisplatin/doxorubicin, highlighting potential drug targets for combination therapies.

4 citations

humanwhole-genome sequencing

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ImmunologybioRxivPreprintNov 18, 2024

Identification of TAP2 protein variants resistant to inhibition by the HSV1 ICP47 protein

Gregory Nagy, Rebecca Presley, Shruti Dhar…·Jeffrey D. Parvin

The paper identifies TAP2 protein variants resistant to HSV1 ICP47 inhibition, which could lead to new antiviral therapies.

DOI 10.1101/2024.11.18.624061

humanprotein sequence

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Cancer BiologybioRxivPreprintSep 30, 2024

Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentation.

Gregory Nagy, Rebecca Presley, Hyeongseon Jeon…·Jeffrey D. Parvin

The paper functionally screens TAP2 variants to show PLK1 overexpression reduces MHC-I surface abundance by phosphorylating TAP2, impairing antigen presentation in cancer cells.

2 citations

humanproteomics

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GenomicsThe American Journal of Human GeneticsPeer-reviewedSep 12, 2018

A multiplexed homology-directed DNA repair assay reveals the impact of ~1,700 BRCA1 variants on protein function

Lea M. Starita, Muhtadi M. Islam, Tapahsama Banerjee…·Jeffrey D. Parvin

The paper develops a multiplex HDR assay to assess the functional impact of ~1,700 BRCA1 variants, distinguishing loss-of-function from benign variants.

120 citationstop 1%

humanDNA methylation

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