Dynamics and Regulation of mRNA Cap Recognition by Human eIF4F
Hea Jin Hong, Matthew G. Guevara, Siyu Li, Yankang Liu, Alexandra N. Huang, Eric C. Lin, Arrmund Neal, Duo Xu, Rong Hai, Roya Zandi, Seán E. O’Leary
This study uses single-molecule fluorescence assays to show that eIF4G represses eIF4E-cap binding, while eIF4A relieves this repression, revealing new insights into eIF4F dynamics and mRNA recognition.
bioRxiv · Jun 26, 2025 · PreprintBiophysics