Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference
Xiangrui Meng, Georgina Navoly, Olga Giannakopoulou, Daniel F. Levey, Dóra Koller, Gita A. Pathak, Nastassja Koen, Kuang Lin, Miguel E. Rentería, Yanzhe Feng, J. Michael Gaziano, Dan Joseph Stein, Heather Joy Zar, Megan L. Campbell, David A. van Heel, , Karoline B. Kuchenbaecker
This paper conducts a multi-ancestry GWAS of major depression, identifying 190 loci and 354 genes, with findings showing increased fine-mapping power and bidirectional BMI relationship in European ancestry samples.
bioRxiv · Jul 20, 2022 · PreprintGenetics