Daniel F. Levey

This study identifies genetic risk loci for nightmare frequency and explores its genetic correlations with psychiatric traits.

This paper conducts a large-scale epigenome-wide association study of PTSD in the Million Veteran Program, identifying 272 CpG sites associated with PTSD traits and replicating prior findings.

This study conducts a multi-ancestry GWAS meta-analysis of 2.5 million participants to identify genetic variants associated with migraine and link them to biological pathways and therapeutic targets.

This study identifies genetic loci associated with fibromyalgia and finds strong genetic correlations with psychiatric and medical traits.

This study links genomic variation to real-time Δ9-THC response in humans, showing associations between CYP3A4 expression and psychotomimetic effects.

This paper conducts a multi-ancestry GWAS of stimulant use disorder, identifies 19 genome-wide significant loci, and finds genetic correlations with other psychiatric and substance use disorders.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study performs a multi-ancestry GWAS of neuroticism, identifying novel loci and improving fine-mapping resolution across diverse populations.

This study identifies 49 CpG sites associated with generalized anxiety disorder across three ancestries but finds limited replication in an independent cohort.

This study identifies 40 genome-wide significant loci for SSRI use and finds genetic correlations with psychiatric and medical traits, suggesting SSRI use is a proxy for MDD with distinct genetic architecture.

This paper develops a semi-empirical Bayesian framework to calibrate weak instrumental bias in sex-specific Mendelian randomization studies, revealing significant sex differences in causal effects of sleep phenotypes on cardiovascular diseases.

This study investigates the genetic basis of physical activity across different contexts and finds that leisure-time activity has distinct genetic influences and protective health effects.

This paper conducts a multi-ancestry GWAS of sleep duration, identifying 234 genome-wide significant loci and showing distinct genetic architecture from other sleep and psychiatric traits.

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

The paper integrates HiTOP and RDoC frameworks to identify shared and distinct biological mechanisms of externalizing and internalizing psychopathology using multi-omics approaches.

The paper uses genomic structural equation modeling to identify the genetic architecture of externalizing and internalizing psychopathology, finding a moderate genetic correlation and shared causal variants.

This paper investigates the causal impact of opioid use disorder on brain health outcomes using observational and genetic analyses, finding increased dementia risk associated with both OUD diagnoses and genetic predisposition to OUD.

This study conducts a genome-wide association analysis of the Big Five personality traits, identifying novel genetic loci and associations with psychiatric traits.

Population-stratified GWAS of 2,068 traits in 635,969 Million Veteran Program participants, 29% genetically non-European, yields 98,485 associations and 57,601 fine-mapped signals with largely shared cross-population architecture.

This study investigates genetic correlations and causal relationships between schizophrenia, cannabis use disorder, and tobacco smoking across African and European ancestries, identifying pleiotropic loci and convergent genetic effects.

This paper identifies shared genetic risk loci between ADHD, cannabis use disorder, and cannabis use, and predicts cannabis use disorder risk in ADHD using polygenic scores.

This study identifies 64 new risk loci for major depression, refines its genetic architecture, and shows strong genetic overlap with other psychiatric disorders and educational attainment.

This paper conducts a genome-wide association study (GWAS) of epiretinal membrane (ERM) in three American populations, identifying significant risk loci and genetic correlations with other traits.

This paper identifies genetic loci associated with short and long sleep duration through a cross-population meta-analysis and explores their genetic correlations and causal relationships with depression.

This study investigates the genetic and longitudinal relationship between posttraumatic stress disorder and coronary artery disease using genome-wide data and electronic health records.

This paper conducts a multi-ancestry GWAS of major depression, identifying 190 loci and 354 genes, with findings showing increased fine-mapping power and bidirectional BMI relationship in European ancestry samples.

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

This paper identifies 15 genome-wide significant loci for maximum habitual alcohol intake (MaxAlc) in 247,755 U.S. Veterans and shows strong genetic correlations with alcohol use disorder and psychiatric traits.

This study investigates genetic overlaps between 12 psychiatric disorders, identifying pleiotropic SNPs and biological pathways, but finds challenges in interpreting shared mechanisms due to varying genetic architectures.

This study analyzes ancestry diversity changes in the Million Veteran Program over time and shows that refined ancestry modeling reduces population stratification in GWAS of height.