NRF2 deficiency promotes ferroptosis of astrocytes mediated by oxidative stress in Alzheimer's disease
Zhi Tang, Zhuyi Chen, Min Guo, Yaqian Peng, Yan Chun Xiao, Zhi-Zhong Guan, Ruiqing Ni, Xiaolan Qi
This study shows that Nrf2 deficiency in astrocytes increases oxidative stress and ferroptosis in Alzheimer's disease by reducing antioxidant proteins and increasing lipid peroxidation.
Molecular Neurobiology · Feb 24, 2024Peer-reviewedNeuroscience