Xiaolan Qi

Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimers disease

This study shows isoliquiritigenin improves cognitive function and reduces tau phosphorylation, oxidative stress, and mitochondrial dysfunction in a mouse model of Alzheimer's disease.

Targeting mTOR restores tau-induced metabolic, mitochondrial, and cognitive deficits in a tauopathy mouse model

This study shows that mTOR inhibition with rapamycin improves cognitive function and metabolic profiles in a tauopathy mouse model by reducing tau phosphorylation and mitochondrial dysfunction.

NRF2 deficiency promotes ferroptosis of astrocytes mediated by oxidative stress in Alzheimer's disease

This study shows that Nrf2 deficiency in astrocytes increases oxidative stress and ferroptosis in Alzheimer's disease by reducing antioxidant proteins and increasing lipid peroxidation.

Gastrodin ameliorates synaptic impairment, reestablishes mitochondrial membrane potential and reduces oxidative stress in N2a/APP cells through the ERK1/2 and GSK-3beta pathways

This study shows gastrodin protects N2a/APP cells by improving synaptic proteins, reducing oxidative stress, and modulating ERK1/2 and GSK-3beta pathways.

Myricetin protected against Aβ oligomer-induced synaptic impairment, mitochondrial function and oxidative stress in SH-SY5Y cells via ERK1/2/GSK-3β pathways

This study shows myricetin protects SH-SY5Y cells from Aβ42 oligomer toxicity by modulating ERK1/2/GSK-3β pathways, reducing oxidative stress, mitochondrial dysfunction, and synaptic impairment.

Quercetin reduces APP expression, oxidative stress and mitochondrial dysfunction in the N2a/APPswe cells via ERK1/2 and AKT pathways