Zhi-Zhong Guan

This study investigates how chemerin-CMKLR1 signaling differentially affects mitochondrial dysfunction, oxidative stress, and autophagy in microglia and neurons under OGD/R conditions.

This study shows that mTOR inhibition with rapamycin improves cognitive function and metabolic profiles in a tauopathy mouse model by reducing tau phosphorylation and mitochondrial dysfunction.

This study shows that Nrf2 deficiency in astrocytes increases oxidative stress and ferroptosis in Alzheimer's disease by reducing antioxidant proteins and increasing lipid peroxidation.