Ruiqing Ni

Toward Pathology-guided Illumination Optimization for Neuromodulation with PhomiNeuro

PhomiNeuro optimizes NIR neuromodulation light fluence using a differentiable surrogate model, improving speed and accuracy for personalized treatment planning.

Divergent scalp-to-region distance alteration patterns in autism spectrum disorders, Parkinson's disease and Alzheimer's disease

The paper develops an automatic pipeline to measure scalp-to-region distances (SRD) in brain diseases and identifies distinct SRD alteration patterns in autism spectrum disorder, Alzheimer's disease, and Parkinson's disease.

Multiscale brain-wide mapping of α-synuclein-driven dopaminergic degeneration and white matter impairment in α-synucleinopathy mice

This paper maps α-synuclein pathology and dopaminergic degeneration in mice using multimodal imaging and microscopy, showing spread along the nigrostriatal pathway and microstructural changes.

Chemerin-CMKLR1 mediated OGD/R induced Mitochondrial Dysfunction, Oxidative Stress, and Autophagy differentially in Microglia and Neurons

This study investigates how chemerin-CMKLR1 signaling differentially affects mitochondrial dysfunction, oxidative stress, and autophagy in microglia and neurons under OGD/R conditions.

Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimers disease

This study shows isoliquiritigenin improves cognitive function and reduces tau phosphorylation, oxidative stress, and mitochondrial dysfunction in a mouse model of Alzheimer's disease.

Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer's disease- associations with Aβ, tau and synaptophysin

The paper examines reduced SV2A levels in AD brain tissue and extracellular vesicles, linking them to amyloid-β, tau, and synaptic markers.

Targeting mTOR restores tau-induced metabolic, mitochondrial, and cognitive deficits in a tauopathy mouse model

This study shows that mTOR inhibition with rapamycin improves cognitive function and metabolic profiles in a tauopathy mouse model by reducing tau phosphorylation and mitochondrial dysfunction.

Hippocampal mGluR5 levels are comparable in Alzheimer's and control brains, and divergently influenced by amyloid and tau in control brain

This study finds no difference in hippocampal mGluR5 levels between Alzheimer's and control brains, but shows amyloid and tau have opposing effects on mGluR5 in controls.

Spinal cord perfusion impairments in the M83 mouse model of Parkinson's disease

The paper uses multimodal imaging to assess spinal cord oxygenation and vascular changes in a PD mouse model, finding reduced oxygen saturation but no vascular impairment or atrophy.

Hippocampal purinergic P2X7 receptor level is increased in Alzheimer's disease patients, and associated with amyloid and tau pathologies

The paper examines increased P2X7R levels in Alzheimer's disease hippocampi, correlating with amyloid and tau pathologies, and identifies its potential as a neuroinflammation marker.

NRF2 deficiency promotes ferroptosis of astrocytes mediated by oxidative stress in Alzheimer's disease

This study shows that Nrf2 deficiency in astrocytes increases oxidative stress and ferroptosis in Alzheimer's disease by reducing antioxidant proteins and increasing lipid peroxidation.

Increased regional P2X7R expression detected by GSK1482160 PET in a tauopathy mouse model

The paper uses PET imaging to detect increased P2X7R expression in a tauopathy mouse model, showing correlation with tau pathology.

Reduced SV2A and GABAA receptor levels in the brains of type 2 diabetic rats revealed by flumazenil PET

The paper uses PET imaging to show reduced SV2A and GABAA receptor levels in the brains of aged T2DM rats.

Relationship between reactive astrocytes, by SMBT-1 imaging, with amyloid-beta, tau, glucose metabolism, and microgliosis in mouse models of Alzheimer's disease

Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion

The paper uses PET and MSOT to observe hypoxia and increased spinal cord metabolism in tMCAO mice compared to sham-operated mice.

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

The paper visualizes alpha-synuclein inclusions and iron deposition in M83 mouse models of Parkinson's disease using in vivo imaging and ex vivo validation techniques.

Analysis of skull thickness, scalp-to-cortex distance and association with age and sex in cognitively normal elderly

The paper develops an automatic pipeline for analyzing skull thickness and scalp-to-cortex distance from MRI data and shows age and sex-related changes in these metrics in elderly individuals.

Gastrodin ameliorates synaptic impairment, reestablishes mitochondrial membrane potential and reduces oxidative stress in N2a/APP cells through the ERK1/2 and GSK-3beta pathways

This study shows gastrodin protects N2a/APP cells by improving synaptic proteins, reducing oxidative stress, and modulating ERK1/2 and GSK-3beta pathways.

Myricetin protected against Aβ oligomer-induced synaptic impairment, mitochondrial function and oxidative stress in SH-SY5Y cells via ERK1/2/GSK-3β pathways

This study shows myricetin protects SH-SY5Y cells from Aβ42 oligomer toxicity by modulating ERK1/2/GSK-3β pathways, reducing oxidative stress, mitochondrial dysfunction, and synaptic impairment.

Coregistered transcranial optoacoustic and magnetic resonance angiography of the human brain

This paper demonstrates noninvasive transcranial MSOT angiography in a human volunteer and validates its anatomical alignment with MRI.

Evaluation of CB2R expression and pyridine-based radiotracers in brains from a mouse model of Alzheimer's disease

This study evaluates CB2R expression and pyridine-based radiotracers in a mouse model of Alzheimer's disease, finding increased CB2R in glial cells but no significant mRNA differences.

Quercetin reduces APP expression, oxidative stress and mitochondrial dysfunction in the N2a/APPswe cells via ERK1/2 and AKT pathways

Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography

This paper demonstrates a 3D visualization method for amyloid-beta deposits in Alzheimer's mouse models using MRI and FMT, showing improved depth resolution compared to 2D methods.

Aquaporin 4 is differentially increased and depolarized in association with tau and amyloid-beta

The paper investigates AQP4 distribution and depolarization in tau and amyloid-beta pathologies using mouse models and imaging techniques.

Rapamycin attenuated zinc-induced tau phosphorylation and oxidative stress in animal model: Involvement of dual mTOR/p70S6K and Nrf2/HO-1 pathways

This study shows that rapamycin reduces zinc-induced tau phosphorylation and oxidative stress in rats by inhibiting the mTOR/p70S6K pathway and activating the Nrf2/HO-1 pathway.

Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

This paper demonstrates non-invasive whole brain imaging of tau deposits using vMSOT and PBB5 probe in P301L mice, showing specific binding and retention in tau-laden regions.

Multi-parametric characterization of brain-wide hemodynamic and calcium responses to sensory stimulation in mice

This study uses a hybrid imaging platform to simultaneously observe hemodynamic and calcium responses in mice brains during sensory stimulation, revealing their complex interplay.

In vivo imaging of cannabinoid type 2 receptors, functional and structural alterations in mouse model of cerebral ischemia by PET and MRI

This study uses PET and MRI to assess CB2R levels and metabolic changes in a mouse model of cerebral ischemia, finding increased CB2R and reduced glucose metabolism in the ischemic striatum.

In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice

This paper characterizes CRANAD-2 for detecting amyloid-beta deposits in Alzheimer's mouse models using multi-spectral optoacoustic tomography and fluorescence imaging.

Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy

This study detects cerebral tauopathy in P301L mice using large-field multifocal illumination fluorescence microscopy and a fluorescent ligand, showing increased probe retention in affected mice.