Cyfip1 haploinsufficiency is associated with white matter changes, myelin thinning, reduction of mature oligodendrocytes and behavioural inflexibility
Ana Isabel Silva, Josephine E. Haddon, Yasir Ahmed Syed, Simon Trent, Tzu‐Ching E. Lin, YATEEN S. PATEL, Jenny Carter, Niels Haan, R. C. Honey, Trevor Humby, Yaniv Assaf, Michael John Owen, David E.J. Linden, Jérémy Hall, Lawrence S. Wilkinson
This study uses a rat model to show that Cyfip1 haploinsufficiency causes white matter changes, myelin thinning, reduced mature oligodendrocytes, and behavioural inflexibility.
Nature Communications · Aug 1, 2019Peer-reviewedNeuroscience