Trevor Humby

Physiological and behavioural characterisation of a novel steroid sulfatase-deficient mouse

This study creates a STS-deficient mouse model and finds sex-specific behavioral and physiological differences linked to STS deficiency.

Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour

This study investigates the effects of Setd1a haploinsufficiency in mice, finding sex-dependent behavioral changes relevant to schizophrenia and suggesting limitations in antipsychotic efficacy.

Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2

This study examines behavioural impairments in heterozygous Dlg2 mice, finding deficits in long-term motor learning and habituation but not motor coordination or anxiety.

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder

This study characterizes the Dlg2 haploinsufficiency rat model, finding reduced PSD-93 expression and specific behavioral changes linked to psychosis vulnerability without other deficits.

Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder

This study shows that complement components C3 and C3aR differentially affect innate anxiety and conditioned fear in mice, linking complement pathways to psychiatric disorder risk.

Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia

The paper compares gene expression in two mouse models of Prader-Willi Syndrome to identify molecular differences associated with psychotic illness versus schizophrenia.

Mice lacking paternal expression of imprinted Grb10 are risk-takers

This study shows that mice lacking paternal expression of Grb10 exhibit increased risk-taking behavior in specific tasks, supporting the idea that imprinted genes influence risk tolerance oppositely based on parental origin.

Cyfip1 haploinsufficiency is associated with white matter changes, myelin thinning, reduction of mature oligodendrocytes and behavioural inflexibility

This study uses a rat model to show that Cyfip1 haploinsufficiency causes white matter changes, myelin thinning, reduced mature oligodendrocytes, and behavioural inflexibility.

Brain gene expression in a novel mouse model of postpartum mood disorder

This study examines brain gene expression changes in mice with STS deficiency and their response to pharmacological treatment, finding limited significant changes but enrichment in olfactory transduction pathways.

Impulsive choice in mice lacking paternal expression of Grb10 suggests intra-genomic conflict in behavior

The paper shows that mice lacking paternal Grb10 make fewer impulsive choices, suggesting imprinted genes influence impulsive behavior and may contribute to pathological conditions.