Jérémy Hall

Gain and loss of function changes in CACNA1C affect neuronal networks through divergent pathways

The paper investigates how loss-of-function and gain-of-function variants in CACNA1C affect neuronal networks and neurodevelopmental phenotypes through divergent mechanisms.

Sex Dependent Effects of Minocycline on Contextual Fear Memory

This study investigates how minocycline affects contextual fear memory in rats, showing sex-dependent differences in its impact on memory reconsolidation, extinction, and forgetting.

Sex differences in latent inhibition and their implications for psychotic disorders

This paper reviews sex differences in latent inhibition, finding inconclusive evidence but suggesting sex differences in hippocampal processing and vulnerability to perturbations.

Reduced gene dosage of the psychiatric risk gene Cacna1c is associated with impairments in hypothalamic-pituitary-adrenal axis activity in rats

This study shows that reduced Cacna1c gene dosage in rats leads to HPA axis dysfunction and anxiety, suggesting a potential mechanism for psychiatric disorder risk.

REDUCED CACNA1C EXPRESSION PRODUCES ANHEDONIC REACTIONS TO PALATABLE SUCROSE IN RATS: NO INTERACTIONS WITH JUVENILE OR ADULT STRESS

Direct pathway bias and altered striatal neurogenesis in human iPSC models of 16p11.2 CNVs: Evidence from single-cell and functional analyses

The paper uses human iPSC-derived medium spiny neurons to show that 16p11.2 CNVs alter striatal neurogenesis and bias toward direct pathway neurons, linking these changes to neurodevelopmental disorders.

Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs)

This study examines irritability in young people with neurodevelopmental copy number variants (ND-CNVs) and finds it is more common than in controls, independent of psychiatric diagnoses or IQ.

Using rare genetic mutations to revisit structural brain asymmetry

The paper investigates how rare genetic mutations affect brain asymmetry by analyzing CNVs in a cohort of individuals and linking genetic alterations to brain structure and function.

Oxysterol-liver X receptor signaling mediates CYFIP1 regulation of cortical neurogenesis

This study shows that CYFIP1 regulates cortical neurogenesis through oxysterol-liver X receptor signaling, with implications for genetic disorders linked to 15q11.2 CNVs.

Control of timing and directionality during neurodifferentiation of human induced Pluripotent Stem Cells (iPSC) via miRNA-mediated feedback and feedforward loops.

The paper identifies a gene regulatory network involving miRNAs that control neuronal differentiation by blocking REST through feedforward and feedback loops, with implications for neurodevelopmental disorders.

Subcortical brain alterations in carriers of genomic copy number variants

This study examines subcortical brain alterations in CNV carriers across multiple neuropsychiatric disorders, finding shared and distinct patterns of structural changes.

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

The paper investigates how eight rare CNVs affect brain structure and phenotypes across 534 carriers, finding structural divergence and phenotypic convergence despite different genetic origins.

Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2

This study examines behavioural impairments in heterozygous Dlg2 mice, finding deficits in long-term motor learning and habituation but not motor coordination or anxiety.

Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity

This study shows that reduced DLG2 expression in rats impairs hippocampal synaptic integration and plasticity, which can be reversed by muscarinic M1 receptor agonists.

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder

This study characterizes the Dlg2 haploinsufficiency rat model, finding reduced PSD-93 expression and specific behavioral changes linked to psychosis vulnerability without other deficits.

Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder

This study shows that complement components C3 and C3aR differentially affect innate anxiety and conditioned fear in mice, linking complement pathways to psychiatric disorder risk.

Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome.

This study investigates the effects of 1q21.1 deletion and duplication on neuronal development using induced pluripotent stem cells and shows reciprocal phenotypes and potential therapeutic targets.

Atlas of functional connectivity relationships across rare and common genetic variants, traits, and psychiatric conditions

The paper examines how rare and common genomic variants affect brain functional connectivity, revealing how polygenicity and pleiotropy influence psychiatric conditions and brain networks.

The general impact of haploinsufficiency on brain connectivity underlies the pleiotropic effect of neuropsychiatric CNVs

Neuropsychiatric CNVs reorganize brain connectivity along shared patterns linked to cognitive traits and disorder severity.

Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders

The paper shows that reduced EHMT1 activity decreases NRSF/REST protein, leading to abnormal neuronal gene expression and neurodevelopmental issues in human iPSCs.

Developmental profile of psychiatric risk associated with voltage-gated cation channel activity

The paper examines the developmental expression of genes related to voltage-gated cation channels and their association with psychiatric disorders, finding that gene expression patterns vary with age and disorder type.

Analysis of diffusion tensor imaging data from UK Biobank confirms dosage effect of 15q11.2 copy-number variation on white matter and shows association with cognition

The paper analyzes diffusion tensor imaging data from UK Biobank to show that 15q11.2 copy-number variation affects white matter and is associated with cognitive performance.

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c

The paper shows that activating neurotrophin receptors with BDNF mimetics can rescue cognitive and synaptic deficits caused by Cacna1c mutations in rats.

Genetic association of FMRP targets with psychiatric disorders

The paper examines the genetic association of FMRP targets with schizophrenia, major depressive disorder, and bipolar disorder, finding enrichment for risk alleles and variants in these disorders.

Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk

This study investigates electrophysiological network changes in adults with neurodevelopmental risk copy number variants using MEG, finding decreased connectivity and network segregation differences.

Haploinsufficiency of the psychiatric risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms

This study shows that Cyfip1 haploinsufficiency disrupts hippocampal neurogenesis by affecting microglial apoptosis and actin dynamics in adult-born neurons.

Neuropsychiatric copy number variants exert shared effects on human brain structure

The paper examines the effects of neuropsychiatric CNVs on brain structure using neuroimaging data and identifies shared anatomical patterns across multiple CNVs.

Early life stress impairs social function through AVP-dependent mechanisms

This study shows early life stress impairs social function and increases AVP expression, which can be mitigated by an AVP receptor antagonist in animal models and correlates with emotional recognition in BPD patients.

Coordination difficulties, IQ and psychopathology in children with high-risk Copy Number Variants

This study examines motor coordination difficulties in children with high-risk Copy Number Variants (CNVs) and finds a strong association with psychopathology and lower IQ.

Information and genetic counselling for psychiatric risks in children with rare genomic disorders

The paper examines parents' experiences with genetic counseling for children with rare genomic disorders, finding dissatisfaction with current services and reliance on non-professional sources for psychiatric information.