Lawrence S. Wilkinson

This study shows that reduced Cacna1c gene dosage in rats leads to HPA axis dysfunction and anxiety, suggesting a potential mechanism for psychiatric disorder risk.

This study investigates the effects of Setd1a haploinsufficiency in mice, finding sex-dependent behavioral changes relevant to schizophrenia and suggesting limitations in antipsychotic efficacy.

This study examines behavioural impairments in heterozygous Dlg2 mice, finding deficits in long-term motor learning and habituation but not motor coordination or anxiety.

This study shows that reduced DLG2 expression in rats impairs hippocampal synaptic integration and plasticity, which can be reversed by muscarinic M1 receptor agonists.

This study characterizes the Dlg2 haploinsufficiency rat model, finding reduced PSD-93 expression and specific behavioral changes linked to psychosis vulnerability without other deficits.

This study shows that complement components C3 and C3aR differentially affect innate anxiety and conditioned fear in mice, linking complement pathways to psychiatric disorder risk.

The paper analyzes diffusion tensor imaging data from UK Biobank to show that 15q11.2 copy-number variation affects white matter and is associated with cognitive performance.

The paper shows that activating neurotrophin receptors with BDNF mimetics can rescue cognitive and synaptic deficits caused by Cacna1c mutations in rats.

This study uses a rat model to show that Cyfip1 haploinsufficiency causes white matter changes, myelin thinning, reduced mature oligodendrocytes, and behavioural inflexibility.

The paper shows that mice lacking paternal Grb10 make fewer impulsive choices, suggesting imprinted genes influence impulsive behavior and may contribute to pathological conditions.