Hepatocyte FGFR2 Mediates the Antifibrotic Effects of FGF10 in Advanced Liver Fibrosis.
Xuanxin Yang, Bingjie Yu, Jiaying Ma, Yawei Yan, Huan Wang, Qingqing Dong, Shuangyan Peng, Qiqi Wu, Tingting Zhang, Panyu Zhang, Zelong Jiang, Chao Lü, Le Li, Xinyi You, Yuandong Xu, , Xiaojie Wang
This study identifies the hepatocyte FGF10-FGFR2 axis as a negative regulator of fibrogenesis, showing it can attenuate and reverse advanced liver fibrosis.
bioRxiv · Nov 18, 2025 · PreprintPharmacology & Toxicology