FTO regulates centrosome function and mitotic fidelity in cancers with chromosome instability (CIN)
Lea Cohen-Attali, Yelena Mostinski, Guy Biber, Daniela Kaludjerski, Mor Hanan, Reut Eshel, Alexandra Polyansky, Igor Pery, Aric Orbach, Rotem Karni, Amir Mor
This study shows FTO regulates centrosome function and mitotic fidelity, with CIN cancers being more sensitive to FTO inhibition.
bioRxiv · Mar 25, 2026 · PreprintCancer Biology