Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy
Eric R. Wengert, Sophie R Liebergall, Teresa Jimenez, Melody A Cheng, Kelly H Markwalter, Jerome Clatot, Yerahm Hong, Leroy Arias, Eric D. Marsh, Xiaohong Zhang, Theodoros Tsetsenis, Ala Somarowthu, Naiara Akizu, Ethan M. Goldberg
This study creates a mouse model with the KCNC1-A421V variant to investigate its effects on neuronal excitability and epilepsy, finding impaired function in fast-spiking interneurons and network dysfunction.
eLife · Feb 18, 2026Peer-reviewedNeuroscience