Eric R. Wengert

Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

This study creates a mouse model with the KCNC1-A421V variant to investigate its effects on neuronal excitability and epilepsy, finding impaired function in fast-spiking interneurons and network dysfunction.

Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome

The paper investigates EAP firing in PVINs from Dravet syndrome mice and finds reduced EAP frequency compared to wildtype controls.

Optimizing clinical interpretability of functional evidence in epilepsy-related ion channel variants

The paper develops a Bayesian framework to integrate functional evidence into clinical variant interpretation for epilepsy-related ion channel genes, identifying key parameters that influence pathogenicity classification.

Parvalbumin Interneuron Impairment Leads to Synaptic Transmission Deficits and Seizures in SCN8A Epileptic Encephalopathy

This study shows that impairments in parvalbumin interneurons due to SCN8A mutations cause synaptic transmission deficits and seizures in a mouse model of SCN8A epileptic encephalopathy.

Developmentally-regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome

This study shows that impaired spike generation and synaptic transmission in parvalbumin interneurons contribute to Dravet syndrome severity and chronic pathology in an experimental model.

Somatostatin-positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy

This study shows that somatostatin-positive interneurons with SCN8A mutations contribute to seizures by causing hyperexcitability and depolarization block.

DNA Methyltransferase 1 and 3a Expression in the Frontal Cortex Regulates Palatable Food Consumption

This study shows that deleting DNA methyltransferase 1 and 3a in the mouse prefrontal cortex reduces palatable food consumption without affecting chow intake, with effects on neuron excitability and DNA methylation patterns.